Sendai virus-specific T cell clones. V. Induction of a virus-specific response by antiidiotypic antibodies directed against a T helper cell clone
نویسندگان
چکیده
We used an antiidiotypic antibody directed against a Sendai virus-specific T helper cell clone to stimulate an immune response in vivo. In addition, the antiidiotypic antibody induced T cells that mediated a delayed-type hypersensitivity (DTH) response in several different mouse strains. Induction of the DTH response by the antiidiotypic antibody, in contrast to the DTH responses induced by virus, demonstrated a remarkable lack of H-2 restriction.
منابع مشابه
Sendai virus-specific T-cell clones: induction of cytolytic T cells by an anti-idiotypic antibody directed against a helper T-cell clone.
We used a monoclonal anti-idiotypic antibody that is directed against a Sendai virus-specific helper T-cell clone to induce an anti-viral immune response in vivo. Splenocytes primed with the anti-idiotypic antibody mediated an antigen-specific cytolytic response. Preimmunization of mice with the anti-idiotypic antibody resulted in protection against a subsequent lethal infection with Sendai virus.
متن کاملProduction and Evaluation of Specific Single-Chain Antibodies against CTLA-4 for Cancer-Targeted Therapy
Background: Cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) molecules are expressed on T-cells and inhibit their function by inhibiting activation of subsequent T-cell molecular pathways. Blocking of CTLA-4 inhibits the growth of malignant tumor cells. Anti-CTLA-4 monoclonal antibodies activate the immune system against cancer. Due to several advantages of single-chain antibodi...
متن کامل838 St 1 Mulatory Antibodies Specific for Helper T Cell Clones
The proliferation of helper T cells and the T-dependent induction of B cell activation are events that are initiated by T cell recognition of antigen in association with Ia glycoproteins. However, the molecular basis of helper T cell antigen recognition remains unknown. Like several other laboratories, we have approached this problem by raising antibodies that are individually specific for func...
متن کاملMulatory Antibodies Specific for Helper T Cell Clones
The proliferation of helper T cells and the T-dependent induction of B cell activation are events that are initiated by T cell recognition of antigen in association with Ia glycoproteins. However, the molecular basis of helper T cell antigen recognition remains unknown. Like several other laboratories, we have approached this problem by raising antibodies that are individually specific for func...
متن کاملCooperation between cytotoxic and helper T lymphocytes in protection against lethal Sendai virus infection. Protection by T cells is MHC- restricted and MHC-regulated; a model for MHC-disease associations
The in vivo importance of class I MHC regulation of the Tc response to a natural pathogenic agent of high virulence was studied on the basis of our previous demonstration of a major difference in the capacity to generate a Sendai virus-specific Tc response between C57BL/6 (B6, H-2b) mice and H-2Kb mutant B6.C-H-2bm1 (bm 1) mice. These two mouse strains differ from each other only in three amino...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 159 شماره
صفحات -
تاریخ انتشار 1984